Molecular characterization of Torque teno virus and SEN virus co-infection with HIV in patients from Southern Iran

Pirouzi, Aliyar and Bahmani, Mirzakhalil and Feizabadi, Mohammad Mehdi and Afkari, Rouhi (2014) Molecular characterization of Torque teno virus and SEN virus co-infection with HIV in patients from Southern Iran. Revista da Sociedade Brasileira de Medicina Tropical, 47 (3). pp. 275-279. ISSN 0037-8682

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Official URL: http://doi.org/10.1590/0037-8682-0073-2014

Abstract

Introduction Torque teno virus (TTV) and SEN virus are circular single-stranded DNA viruses that cause blood-borne infections. The SEN virus (SEN-V) was originally detected in the serum of an injection drug user infected with human immunodeficiency virus (HIV). Recently TTV was discovered as a potential causative agent of non-A-E hepatitis. The aim of this study was to investigate the prevalence of the SEN-V-D/H and TTV in HIV patients and healthy blood donors in Iran. Methods One hundred and fifty HIV patients with a mean age of 50.46 ± 18.46 years and 150 healthy blood donors with a mean age of 48.16 ± 13.73 years were included in this study. TTV and SEN-V were detected by the PCR and were quantitatively assayed by competitive PCR (nested and semi-nested PCR). Restriction fragment length polymorphisms (RFLPs) were used to determine the heterogeneity of TTV. Results TTV and SEN-V were detected 96 (64%) and 84 (56%) of 150 HIV patients respectively. These rates were 34% (n=51) and 37.33% (n=56) in healthy blood donors (significant, p<0.05). PCR detected SEN-V/TTV DNA from 32 of the healthy blood donors (21.33%), while 65 (43.33%) of HIV patients were positive for SEN-V/TTV DNA. Of 150 HIV patients, 32.66% and 23.33% were positive for SEN-V-H and SEN-V-D, respectively and 18.66% (n=28) were co-infected with SEN-V-D/H. Conclusions The prevalence of SEN-VD/H and TTV is higher in HIV patients than in healthy blood donors in Southern Iran. Our results suggest that TTV and SEN-V might play a role in the development of liver disease in patients with immunodeficiency diseases. Key words: Torque teno virus; SEN virus; HIV; Genotype; Blood donors

Item Type: Article
Subjects: Virology
Depositing User: Unnamed user with email webgerash@gmail.com
Date Deposited: 29 Dec 2019 07:05
Last Modified: 29 Dec 2019 07:05
URI: http://eprints.gerums.ac.ir/id/eprint/37

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